What is Cymbalta?

Cymbalta affects chemicals in the brain that may become unbalanced and cause depression.

Cymbalta is used to treat major depressive disorder and general anxiety disorder.

Cymbalta is also used to treat a chronic pain disorder called fibromyalgia, treat pain caused by nerve damage in people with diabetes (diabetic neuropathy) and to treat chronic musculoskeletal pain, including discomfort from osteoarthritis and chronic lower back pain.

Cymbalta may also be used for purposes not listed in this medication guide.
Important information about Cymbalta

Do not use Cymbalta together with thioridazine (Mellaril), or an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). A dangerous drug interaction could occur, leading to serious side effects.

You may have thoughts about suicide when you first start taking an antidepressant such as Cymbalta, especially if you are younger than 24 years old. A dangerous drug interaction could occur, leading to serious side effects. You must wait at least 14 days after stopping an MAO inhibitor before you can take Cymbalta. After you stop taking Cymbalta, you must wait at least 5 days before you start taking an MAOI. Do not use Cymbalta if you are allergic to duloxetine, or if you have untreated or uncontrolled glaucoma.

To make sure you can safely take Cymbalta, tell your doctor if you have any of these other conditions:

* liver or kidney disease;
*seizures or epilepsy;
*a bleeding or blood clotting disorder;
*glaucoma;
*bipolar disorder (manic depression); or
*a history of drug abuse or suicidal thoughts.

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. It is not known whether Cymbalta will harm an unborn baby. However, Cymbalta may cause problems in a newborn if you take the medicine during the third trimester of pregnancy. *constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Cymbalta side effects (in more detail)
What other drugs will affect Cymbalta?

Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with Cymbalta may cause you to bruise or bleed easily.

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, or anxiety can add to sleepiness caused by Cymbalta. Tell your doctor if you regularly use any of these medicines, or any other antidepressant.

Tell your doctor about all other medicines you use, especially:

*a blood thinner such as warfarin (Coumadin);
*cimetidine (Tagamet);
*a diuretic (water pill);
*fluvoxamine (Luvox);
*linezolid (Zyvox);
*lithium (Lithobid, Eskalith);
*St. John's wort;
*tramadol (Ultram);
*tryptophan (sometimes called L-tryptophan);
*an antibiotic such as ciprofloxacin (Cipro);
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Published January 19th, 2012

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