Lately, there's new trojan horse attacking computer system and pendrive, called "Flash.10.Setup.exe".

Some of my friend's computer has been infected by this annoying trojan horse.

Trojan Info :-
-Also known as Trojan.Win32.VB.ayo / TR/VB.ayo.1
-It can change the settings of your computer system

How To Get Rid Of This Trojan ?
- As far as I know, If you have latest virus definition updates of anti-virus like AntiVir or Kapersky, then you'll be able to detect and delete the trojan.
-Sometimes, it resides in C:/windows/system32 .When you open the directory, your anti-virus will be able to detect it.
-If you're not sure whether the trojan is definitely gone, use HijackThis to verify all the related files are gone. IF you found something like REG:Win.ini: load=Flash.10.exe, "check" the button next to the file and click "Fix it".
-Your computer should be fine..

Advice For Pendrive User:-
-Before opening the pendrive, it is recommended to scan it first.
-This Flash.10.Setup.exe usually will automatically run if you just browse the pendrive without scanning it first.
-IF your anti-virus is able to detect it, after deleting the trojan then you have to manually delete the Autorun.inf file ( this file is hidden )

p/s : Hope this guide will help you to get rid of this trojan.

Source Info from: 

http://tweak-everything.blogspot.com