The coagulation of blood is a
complex process during which
blood forms solid clots. It is
an important part of
hemostasis (the cessation of
blood loss from a damaged
vessel) whereby a damaged
blood vessel wall is covered
by a fibrin clot to stop
hemorrhage and aid repair of
the damaged vessel. Disorders
in coagulation can lea
more

The coagulation of blood is a
complex process during which
blood forms solid clots. It is
an important part of
hemostasis (the cessation of
blood loss from a damaged
vessel) whereby a damaged
blood vessel wall is covered
by a fibrin clot to stop
hemorrhage and aid repair of
the damaged vessel. Disorders
in coagulation can lead to
increased hemorrhage and/or
thrombosis and embolism.

Coagulation is similar in
mammals, with all mammals
using a combined cellular and
serine protease mechanism. The
system in humans is the most
extensively researched and
therefore the best known. This
article focuses on human blood
coagulation

In a normal individual,
coagulation is initiated
within 20 seconds after an
injury occurs to the blood
vessel damaging the
endothelial cells. Platelets
immediately form a haemostatic
plug at the site of injury.
This is called primary
haemostasis. Secondary
haemostasis then
followsâ??plasma components
called coagulation factors
respond (in a complex cascade)
to form fibrin strands which
strengthen the platelet plug.
Contrary to popular belief,
coagulation from a cut on the
skin is not initiated by air
or drying out, but by
platelets adhering to and
activated by collagen in the
blood vessel endothelium. The
activated platelets then
release the contents of their
granules, these contain a
variety of substances that
stimulate further platelet
activation and enhance the
haemostatic process.

Category Film & Animation

Tags primary, haemostasis, initiated, platelets, blood, clotting, wounds, loss, coagulation, cut, wound